Lung cancer is a leading cause of cancer death. In recent years genome sequencing has revealed insights into the driving events and mutational processes associated with tumour development. This work has identified genomic guided treatment opportunities and revealed features of immune response in the tumour and tumour immune micro-environment. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique that can sample potential tumour regions to aid in diagnosis. This talk will provide an overview of genomics in lung cancer. In addition we will present some of our findings in a large cohort of lung samples collected via EBUS-TBNA that underwent whole genome sequencing.